City Center

City Center, Las Vegas is made up of multiple skyscrapers with contemporary designs. The inside is just as lavish as the outside, where world famous artists have put in there own tweeks and installations to make City Center one of a kind. Combined City Center has 2,400 condominium and condo hotel units and approximately 4,800 hotel rooms. They are all distributed within several high rise and mid rise towers around the â€Å"CRYSTALS† retail and entertainment district. The multi use project is designed with green technologies to make it one of the world's largest environmentally sustainable urban communities. Private investors had to dish out 11 Billion dollars for the funding to build this extravagant addition to Las Vegas. City Center’s opening will boost Las Vegas economy when the country gets back on its feet after the economic collapse. Right now at least 50% of the 12,000 employees are only working part-time which means when business picks up more people will be getting paid and that puts money straight into Las Vegas businesses. I did the research about what materials were used to build this massive project and this is what I found: FACILITY †¢ 7,000 guest rooms across 5 separate buildings City Center resort & casino will tower 60 stories †¢ 165,000 sq ft casino †¢ 70,000 sq ft spa †¢ 2,000 sq ft theatre PROJECT SCOPE Hollow Metal Doors, Hollow Metal Frames, Architectural Wood Doors, Architectural Hardware, Rolling Steel Doors, Architectural Mouldings and Trim. Project Owner: MGM Mirage General Contractor: Perini Construction Architect: HKS Architects, In c. Project Amount: $9. 8 Billion Completion Date: December 2009 60% of the remains of the former hotel that occupied the lot, The Boardwalk hotel, were used for the construction of the project.

Noughts and Crosses Essay

English teachers don’t need to be told the enormous value and pleasure of reading whole texts as class readers. Little compares with that feeling when a class are truly engaged in the reading of a really good book. Those moments stay with you forever – indeed, they fuel the desire to find another such book to repeat the experience, again and again. Fortunately, contemporary writers of fiction for young adults continue to offer us fresh opportunities to enjoy literature with our students. Oxford Rollercoasters is a series that offers teachers the opportunity of studying first-class novels – recently written for teenagers – as whole-class readers with Year 7, 8 and 9 students. Focus on assessment of reading Oxford Rollercoasters includes titles with varied themes, challenging subject matter and engaging plots – for example, Noughts and Crosses takes a very contemporary slant on racism, Firestarter features a modern-day compulsive arsonist, while Fire, Bed and Bone is set during the Peasants’ Revolt. Each novel is accompanied by innovative and engaging teaching materials, specifically designed to help students access the texts and to support learning as required by the National Curriculum. Rollercoasters is firmly based on the reading objectives in the Framework, and draws on approaches to reading fiction recommended by the English strand of the Secondary National Strategy. The series is written by practising teachers and consultants, and, while concentrating on the explicit teaching of reading skills, also draws on approaches to literature through drama and media. Theories behind both assessment for learning and thinking skills are also embedded in the materials. Time-saving resources For each Rollercoasters novel there is a set of Lesson Plans, specifying particular objectives, assessment focuses and learning outcomes. These are accompanied by a compact Overview (see page 4) which summarizes the scheme at a glance, including the necessary resources for each lesson. The Navigator offers a clear plot summary, linked to relevant chapters, to help speedy location of particular parts of the novel. Lesson Plans are accompanied by full, varied and practical Worksheets and OHTs, and drama activities are common within the teaching schemes. The worksheets and OHTs are customizable to meet the needs of a particular teacher and class. For every novel there are suggested guided reading sessions as well as the opportunity to develop further specific group teaching. Class, shared and independent reading are also fully supported in the Lesson Plans. The practice of keeping some form of Reading Journal during the study of the novel is encouraged in many of the schemes, and there are several attractive models for such record-keeping across the teaching materials. Every set of Lesson Plans ends with its own student Reading Assessment Progress Sheet, which the teacher can then use to identify areas for development for each student. Reading Guide Each of the novels has its own student Reading Guide, which contains a rich variety of material to help to engage students in their study of the novel. Each one features unique author’s craft material, giving students a great insight into the writing, editing and publishing process. Ideas for wider reading and for the extension of independent reading are also provided in the Pathways section at the end of the Reading Guide. Website support The Rollercoasters website provides access to the free on-line teacher’s resources, sample chapters of the novels and further author information. Oxford Rollercoasters provides first-class teaching resources for first-class contemporary fiction. The series is designed to engage the widest possible range of students in reading for pleasure, and we feel confident that it will contribute to those memorable experiences of reading together in the secondary classroom.

The Scarlet Letter: Light vs Dark

Defined as a technique of contrasting dark and light to highlight elements within a piece of art or a story, chiaroscuro is displayed throughout The Scarlet Letter by Nathaniel Hawthorne. Also prevalent in many masterpieces created by Rembrandt during the 17 century, Rembrandt uses chiaroscuro to create a focal point in his paintings and evoke personal thought. Hawthorne uses chiaroscuro to focus on the element of overall sin and to illustrate conflicts between characters.A comparison of chiaroscuro in Rembrandts paintings and Hawthorne’s The Scarlet Letter, provides a deeper understand of how light and dark play a key role in the development of characters and theme. Sin is one of the most important themes in The Scarlet Letter. Throughout the novel, Hawthorne presents nature as being evil. For example, the forest displays a moral wilderness that is encompassed within a dark and gloomy atmosphere. However in Chapter 18, Hawthorne uses chiaroscuro as a device to show a change i n the forest as Hester succumbs to the evil of nature and of her sin.â€Å"†¦she undid the clasp that fastened the scarlet letter, and, taking it from her bosom, threw it†¦All at once, as with a sudden smile of heaven, forth burst the sunshine, pouring a very flood into the obscure forest†¦Ã¢â‚¬  During this scene, Hester releases herself from the burden that the scarlet letter brings. As Hester gives into her natural instincts, the forest around her slowly begins to brighten and become overcome by light. This new found light in the forest that grows hand in hand with Hester’s happiness is shown to be good and/or normal based on Hawthorne’s tone.He focuses on the beauty of the light and how it highlights every living thing in the forest, almost in an angelic way. The tone and use of chiaroscuro in this passage allows the reader to believe that giving into your natural instincts and wants is not necessarily wrong or sinful, but nothing more than a part of life. Rembrandt uses a similar approach in using chiaroscuro in his painting Nightwatch (1642). Rembrandt does not use the light to focus on a certain character or object in the painting; rather he exemplifies the different patterns of the painting by creating a battle between light and shadows.The effect of using light and dark in this painting is not meant to provoke meaningful thought, but rather to display an almost chimerical union between the light and dark, similar to the effect displayed by Hawthorne in the forest scene. Hawthorne also uses chiaroscuro to show conflicts between characters and the difference in their personality or spiritual well-being. â€Å"Old Roger Chillingworth, throughout life, had been calm and temperament, kindly, though not of warm affections†¦.Sometimes, a light glimmered out of the physician’s eyes, burning blue and ominous, like the reflection of a furnace†¦Ã¢â‚¬  Roger Chillingworth, Hester’s husband, is presented to the readers as a respectable man that was very upright and devoted to his job and those around him; however, he lacked any sense of passion or love. Once Chillingworth found out that Hester had committed adultery and would not name the father of her bastard child, it became Chillingworth’s mission to uncover the man that had lain with his wife in sin.He must search deep within Dimmesdale, minister for the town and who Chillingworth believes is responsible, using both human and supernatural remedies to extract the secret with no intention of forgiving Dimmesdale. Whereas Dimmesdale is seen as a trustworthy man for the Puritan citizens to bestow their own sins upon, ones of which Dimmesdale helps them to repent. Dimmesdale committed a sin in the eyes of the Puritan society, one born from his need to follow his natural instinct in which Hawthorne states to be good and later admitted to the masses that he was indeed the father and the second perpetrator in this earthly crime.â₠¬Å"And, as he drew towards the close, a spirit as of prophecy had come upon him†¦it was as if an angel, in his passage to the skies, had shaken his bright wings over the people for an instant- at once a shadow and a splendor- and had shed down a shower of golden truths upon them. † This quote displays the way that the Puritan people saw their pastor, a man that was both physically decaying before their eyes, but yet lit up by the word of the gospel. Dimmesdale would then follow his sermon with the confession of his sin, the last act of his mortal life.Hawthorne uses chiaroscuro to depict the difference in the type of evil within the characters of Dimmesdale and Chillingworth. Chillingworth is a man that did not sin in the terms that Dimmesdale did, however, he searches for it without the intent to forgive. Hawthorne expresses this as true evil and sin compared to Dimmesdale’s act of following his natural instinct, which is not a sin. Rembrandt uses chiaroscuro to d epict the character or personality within his paintings. In Self Portrait as St. Paul (1661), the man in the panting is lit while the background and his facial features are considerably darkened.The dark eyes and background represent a type of detachment, whether the detachment is due to an outward or inner struggle. The light of the picture gives one the sense that the man is important or respected. However, the dark causes the audience to believe that the man is in a great deal of struggle or woe, possibly causing him to be dark and cold in the sense of personality, like the depiction of Chillingworth depicted by Hawthorne.Nathaniel Hawthorne uses a device known as chiaroscuro, contrasting light and dark elements, to help develop the characters and theme within The Scarlet Letter. The way Hawthorne displays this development can also be viewed in pieces by Rembrandt. Sin is portrayed in many ways throughout the novel. The forest is used as a symbol of moral bareness of which Hester succumbs to when she takes off the scarlet letter and releases herself from her sin. At this moment, the dark dreary forest is flooded with heavenly beauty of light and life.This play with shadowing and light elements can be viewed in Nightwatch by Rembrandt. This paitning expresses a link between the light and the dark and how they can exist at the same time, however one will always triumph. In the case of the forest scene, the light and the happiness of Hester triumphed over the evil that surrounds her. Hawthorne draws his characters out by having one behold elements, Roger Chillingworth, and the other character behold elements of light, Minister Dimmesdale.Hawthorne then goes deeper to express that the darkness of one might not be of evil intention, but rather dulled by everyday sin of which the light could be redeemed. Rembrandt displays this in the paint Self Portrait as St. Paul, showing how shadows can make one look disconnected and spiritually or emotionally barren. Chiaros curo is a tool used in both the literary and arts world that can help to evoke more emotion and audience thought. Without it, the characters and imagery would all be caught between shades of gloomy greys.

Service Product Marketing Essay Example | Topics and Well Written Essays - 3500 words

Service Product Marketing - Essay Example To assist with process of analysing this statement, definitions of experience, services and goods are set out below. There are of course variations of the definitions available to describe experiences, services and goods. Another consideration is the relationship between experiences, services and goods plus whether each is clearly distinctive from the other especially if one considers how closely related they are to each other. Where it has been considered relevant political or economic backgrounds have been included to give this work greater depth. Experiences are what people have felt or feel when they use goods and services providing the basis for future purchases and behaviour. Providing good experiences can be the key to commercial success. People can buy goods and services because they want to do so or because they have to. The portrayal that some goods and services can provide certain kinds of experiences can make people think need rather than just want goods and services (Ison, 2000, p.48). Economists used to concentrate almost exclusively on the economic experiences of companies and manufacturers rather than the experiences of the consumers of services and goods. It was generally believed that the experiences of companies were distinct from any services and goods that they offered. However the economic experiences of firms should be analysed to make the delivery of services and goods more effective and cheaper to provide. The link between using experiences to lower costs and pass on the savings to customers in the form of lower prices was appreciated by aircraft and car makers during the 1920s, and if Henry Ford’s adoption of mass production method is taken into account earlier than that. In other words it is a different slant on the theories relating to economies of scale (Schnaars, 1998, p. 45). More recently economists, market researchers and

Sermon on mount Essay Example | Topics and Well Written Essays - 1750 words

Sermon on mount - Essay Example ‘ To love is to will good for someone’ (Kraut, 3-20) Thus, it is sensible to do all we can to see a different person get and have a good life no matter how great ones life does not seem to be. The need to write on the topic on the sermon on the mount is to clarify various confusions cited by people each time on the relevance of the topic (Prabhavananda, 13). Using different theories of various philosophers is important to create a substantial evidence as well as to leave any unanswered questions answered fully. Some critics have paid tribute to it since it is the best benevolent teachings in time immemorial, and considering the fact that the teachings can be taken literally. They give an example of St Francis of Assisi the man who risked his life to assist other individuals in the society. He gave up everything and lived in abject poverty to see other humans live comfortably. Another example of one who gave up everything and whose actions can be compared to the teachings in the beatitudes is Padre Pio. He gave up everything and the only wealth he remained with were his priesthood veil, and a pair of sandals just to watch others have a better life. â€Å"How then can the focal point of the sermon on the mount be a sentence that says, ‘be perfect’? and be perfect ‘just as god is perfect’?† (Vaught, 4). This chapter involves proving the fact that the teachings from the sermon in the mount are substantial enough to prove the fact that justice over powers injustice, and that the just live a more fulfilling life than the unjust. From this confusion and argument, substantial evidence is needed to give the people the most suitable answer. Thesis Statement On the issue of whether justice or injustice is important, I take the side of justice being the best and choose to argue out the point in various perspective. Using various points and theories to prove the importance on the message about justice in the beatitudes is essent ial. Using theories like that of Plato, Aristotle, Nitsche and Jesus is essential. Argument 1 In Plato’s Reasoning theory, he supports the fact that justice is better compared to injustice. Plato defines justice as well as its characteristics. He further explains the point that when a city is just, its inhabitants will always live at peace with each other without much ado (Ashbaugh, 48). Plato uses this theory to challenge the sophophists as to why one has to live morally in this life. Comparing this to the teaching on the sermon on the mount, is clear that a just person is one ruled by reasoning. Reasoning is Plato explains that of the three human energies; reason, appetite and emotion, reason surpasses all the other two (Ashbaugh, 7). Plato said, â€Å"Morality is a necessary cause of happiness, one’s happiness is correlary to ones moral behavior.† â€Å"Therefore, an immoral person would be motivated to be moral if he wants to be happy. The happy person is t he just person† (Taylor, 10-23). His is proof that the sermon on the mount’s teachings on living justly to be happy, and for the satisfaction and peace of soul is proof that a just person is happier than the unjust person (Wagner, 4). Argument 2 I quote Aristotle â€Å"The hearer is the one who determines the speech’s end and object.† (Kraut, 3-20) This may present the Sermon on the mount as a more that Jesus might have said

King Lear - Free topic (your choice) Research Paper

King Lear - Free topic (your choice) - Research Paper Example Themes in Alice in Wonderland Throughout the course of Alice’s Adventure in Wonderland, Alice goes via a mixture of bizarre physical changes. The discomfort that she experiences acts as a symbol for the changes that manifest amid puberty in which she finds the changes as traumatic and experiences discomfort, frustration, and sadness (Chastain 23). Alice constantly finds herself in circumstances in which she risks death, and whereas these threats never materialize, they point out that death lurks behind the absurd events encountered during Alice’s Adventures in Wonderland. Death may be a significant threat, and Alice starts to comprehend that the threats she encounters may not be entirely absurd. Themes in Wasteland The major themes in Waste Land themes encompass death, rebirth, the seasons, lust, and love. Death in the poem can translate to mean life whereby in dying a being can shape the way for fresh lives. The Christ images within the poem, accompanied by numerous re ligious metaphors, hypothesize rebirth and resurrection as key themes. Eliot’s vision remains essentially of a world that is neither living nor dying; to discontinue the spell, a dramatic change is necessary (Bloom 250). The depiction of that spring as cruel can be regarded as a surprising choice on Eliot’s part; although can bear regarded as a paradox it shapes the rest of the poem to a significant degree. What generates life equally heralds death; the seasons vary, altering from one state to another, although, like history they maintain some form of stasis. In the end, Eliot’s Waste Land can be regarded as almost season less without rain, of real change, and of propagation. Themes in Dubliners Restrictive routines, plus the tedious, mundane details of each day mark the lives of Joyce’s Dubliners and entrap them within circles of disappointment, self-control, and violence (Ingersoll 21). Routine impacts on characters that face who face difficulty predica ments, but it also impacts on characters who bear little open conflict in their lives. Farrington’s work reflects his social and home life yielding his anger, and abusive behaviour, to worsen. With his explosive physical reactions, Farrington mirrors more than any other characters the brutal ramifications of a repetitive existence. The Interconnection of Life and Death Dubliners opens with â€Å"The Sisters† that examines death and the process of memorizing the dead, and close with â€Å"The Dead,† which appeals to the tranquil of the snow that envelops the dead, plus the living. These narratives bookend the collection and highlight regular focus on the meeting point between life and death. The encounters depicted in meeting the newly dead and living, as is the case of â€Å"A Painful Case,† unreservedly explore this meeting point indicating the forms of aftershocks that death can have for the living. Themes in Strange case of Dr.Jekyll and Mr. Hyde The m ost prominent theme in Dr. Jekyll and Mr. Hyde can be regarded as good vs. evil. Dr. Jekyll and Mr. Hyde are readily perceived as an allegory about the good and evil present in all men, as well as the struggle with the two forms of the human personality (Stevenson 11). The repression in this case entails Victorian England in which there are no sexual appetites, no significant expressions of emotion, and no violence. The violence within the novel

Nursing 220 topic, any age group, relatd to oncology, hematology, Essay

Nursing 220 topic, any age group, relatd to oncology, hematology, immunology, acute neurology, emergency or critcal care nursing - Essay Example ach utilizing the evidence from current nursing research literature so the best nursing practice in this specific area of oncologic nursing practice is established. Review of Literature: Stanley in her note, "Partners in Cancer Care" published from Oncology Nursing Society has highlighted the importance and availability of best evidence for managing common cancer symptoms. Evidence in support of nursing practice in this area is known to be accumulating exponentially, which demands utilization of these evidences in the clinical practice. Literature consistently demonstrates identifiable evidence base for oncology nursing and the impacts of these evidence-based interventions in patient outcomes as far as the oncology nursing practice is concerned. It is also important to evaluate the effectiveness of these interventions used for cancer symptom management, so recommendations for future practice can be made to result in improvement in patient care that can be measured. (Stanley, KJ., 2006). Nausea and vomiting continues to be significant side effects of cancer therapy that add to the distress of the patients. Optimal antiemetic prophylaxis in cancer patients receiving chemo and radiotherapies has been the subject of many trials. The Antiemetic Subcommittee of the Multinational Association of Supportive Care in Cancer (MASCC) in their review presents the findings up to the year 2004. Classically, the chemotherapeutic agents have been classified with high, moderate, low, and minimal emetogenic potentials. The current recommendations support a three-drug regimen that includes a 5-HT3 antagonist such as ondansetron 32 mg, dexamethasone 12 mg, and aprepitant 125 mg on day 1, followed by dexamethasone 8 mg daily on days 2 to 4, and aprepitant 80 mg on days 2 to 3 provides a complete response of no emesis with no use of rescue antiemetic in prevention of vomiting and nausea induced by chemotherapy of high emetogenic risk. Likewise, there are recommendations for moderate

Business plan for starting Mountview Park in Broomfield Term Paper

Business plan for starting Mountview Park in Broomfield - Term Paper Example The Mountview Park is proposed to be a unique dinner and entertainment experience for the local people from around Broomfield, tourists from around America and other countries who visit Colorado’s rocky mountain. The business mission of Mountview Park is â€Å"to establish a multicultural restaurant for the customers to entertain in views of rocky-mountains†. In today’s changing business environment, developing business strategies and structuring business mission with a view to acquire and retain customers and to ensure customer satisfaction have become the core to the heart of preparing an effective business plan (Crego, Schiffrin and Kauss, 1995). The Mountview Park considers measuring and evaluating customer satisfaction as the primary tool to be used for gaining insight in to values and needs of prospective customer base.   With a vision to discover emerging business opportunity, transform the opportunity to business reality and design and develop newer foo d and various multicultural organic food for meeting the needs of those who come to rocky mountains to entertain, the company thrives to function as a dynamic and sophisticated resort. The major business objectives of Mountview Park includes:†¢Ã‚  Serving the customers an excellent combination of organic food and drinks, †¢Ã‚  Establish a unique natural park where customers are free to entertain in areas of rocky mountains of Colorado, and†¢Ã‚  Build stronger customer loyalty... The business mission of Mountview Park is â€Å"to establish a multicultural restaurant for the customers to entertain in views of rocky-mountains†. In today’s changing business environment, developing business strategies and structuring business mission with a view to acquire and retain customers and to ensure customer satisfaction have become the core to the heart of preparing an effective business plan (Crego, Schiffrin and Kauss, 1995). The Mountview Park considers measuring and evaluating customer satisfaction as the primary tool to be used for gaining insight in to values and needs of prospective customer base. With a vision to discover emerging business opportunity, transform the opportunity to business reality and design and develop newer food and various multicultural organic food for meeting the needs of those who come to rocky mountains to entertain, the company thrives to function as a dynamic and sophisticated resort. The major business objectives of Mountv iew Park includes: Serving the customers an excellent combination of organic food and drinks, Establish a unique natural park where customers are free to entertain in areas of rocky mountains of Colorado, and Build stronger customer loyalty by converting each customer who once visits to the park to be an asset of long term profitability. The Park will provide 24/7 services and online booking and other facilities for customers from other countries. As its Financial management planned, it would achieve a gross revenues of more than $ 25, 00,000 by the sixth month and to reach total sales of more than $80,00,000 by the end of first business year. It also plans to increase

Business Proposal-ECONOMICS Essay Example | Topics and Well Written Essays - 750 words - 1

Business Proposal-ECONOMICS - Essay Example As there are high number of sellers and producers our product will have an edge over the other products as we have the latest technology for the making of leather shoes. Technology has helped us lower the cost by reducing labor cost. As it is homogenous product, it will be sold at a price determined by the market but our quality at that price will be the best as compared to our competitors (Boyes, 2013). The selected product is elastic as change in the price of the product will also change the demand of the product. An increase in price can cause a fall in the demand of the product and by such market response we know that the market is competitive and there can be a difficulty in making more profit. As there is a difficulty in increasing profit, we will introduce our product at a lower cost while maintaining a high quality in the market (McEacher, 2013). The price of my product with the provided quality will be low as compared in the competitive market, so if there will be an overall increase in the prices of shoes it will not affect the demand of my product as compared to those of my competitors in the market and the demand of my product will be less elastic. If the price of overall footwear decreases, the demand of our product will be elastic as we will also lower our prices because our variable cost is low due to less labor cost. Pricing will have an impact on our business because if the price of footwear falls we will earn less profit than we are earning at the current market price. The theories of economics explain that a firm should keep on producing a product until its marginal cost becomes equal to its marginal revenue because it is the point where the profit is maximized. Quantity supplied will keep on increasing until we are earning the more revenue than cost from an additional unit. As discussed above our prices will be low in the market therefore we can produce more to earn more revenue

U A Fanthorpe writes powerfully about those who are most disempowered Essay Example for Free

U A Fanthorpe writes powerfully about those who are most disempowered Essay I think U A Fanthorpe does write powerfully about people who she thinks are disempowered. She does this very subtly and cleverly. She always looks at things in two perspectives one is from a dominating person and the other from a weak person who she supports. She, like Shakespeare uses various techniques to convey sympathy towards the weak people and her ideas to the reader. She uses very emotive and powerful language. I dont think that powerful writing just means strong language or words; the structure of the poem and the things she compares to could also reflect powerful writing. I think if people have confidence in themselves and who know what is right, would empower them. I think she is sympathetic towards the disempowered people. Writing about them shows this. In every poem she writes she uses italics to introduce new voices or characters. In Old Man, Old Man the old man is the disempowered person and the narrator is powerful. This is poem is based on the theme of old age, he left for himself when he saw better. In the beginning the old man was in control of everything, didnt need help but by the end he lost control and he felt helpless. and small things distress: Ive lost the hammer. It was also hinted that he was stubborn, disobedient and also had a short temper.no power to arouse your surliness. There are a lot of techniques used by Fanthorpe to reveal what she thought about the old man. Fanthorpe uses alliteration to give the sentence a bit more meaning and punch, garage and garden these harsh consonant sounds give it a bit more emphasis to it. She also makes use of imperatives let me find your hammer. Let me walk with you to drury lane. I am only a cloud; the last stanza is a good example. In You Will Be Hearing From Us Shortly the interviewer is the powerful person and the interviewee is the disempowered one. This is based on a theme of middle age. At the beginning the interviewee has a bit a confidence but by the end of the poem he has lost it completely and he/she never gets a chance to speak. In this poem the vocabulary used is quite sophisticated, words like adequate are used instead of suitable; perpetuate is used instead of continue etc. Fanthorpe ridicules the interviewer and she exaggerates the characters villainous voice. Rhetorical questions are used to quite some affect, most of the stanzas end in these questions personally have to offer?; to defend their relevance; Would you say; And you were born-?. Alliteration is also used, Domestic disasters shimmer. I think that the interviewer is very sarcastic and insulting. In Half Past Two there are three characters so its hard to decide whos the powerful and whos the disempowered. I think that the narrator is the powerful one as she is very dominating and the child is the disempowered one as he is confused about the mature and adult world he has been put into suddenly. The vocabulary used is very casual and child like. The words like timeformykisstime, onceupona, gettinguptime, and tvtime are often used by young children and this shows that the child has a daily routine, when changed from it the child gets scared and needs support. There is a lot of repetition, capitals and alliteration used; the word time itself is repeated 19 times in the whole poem. Alliteration is used to show that the child cant tell time of a clock, he couldnt click its language. Capitals are used to emphasise the words. The poems themselves have one significant thing in common; there is always an authority person and a disempowered person. In most of her poems there is always an atmosphere of war, good and evil. Fanthorpe uses narrative technique very cleverly; this is particularly effective, as this does not completely reveal the identity of the narrator. This technique can create an atmosphere of tension and suspense. This creates sympathy for the disempowered from the reader. By using this technique, I am only a cloud, somehow the readers feel much more involved with the poem because it was written in first person. The readers can imagine the situation better and sympathise with the disempowered as if it was the readers who are the disempowered. She ridicules the authoritive figure by making their characters villain like and making them look as if they are the worst people on earth. Some of Fanthorpes writings are based on real life events, which contribute to their cultural, historical and social contexted writings. The setting of Old Man, Old Man in London proves this. You Will Be Hearing From Us Shortly is an everyday stereotypical interview, which could happen anywhere. Half past two and Old man, old man have a similar structure and form but in comparison to You will be hearing from us shortly there is a stark contrast, it is written in a conversational manner. This adds to the meaning that its an interview and there are two people speaking and there is no narrator. If you look at Dear Mr Lee another one of Fanthorpes poems, it is more like a long story or essay than a poem divided into stanzas that is quite different to any of her other poems. She tries to vary her style of writing a bit from poem to poem. Most of the language she uses is informal but some of her vocabulary is sophisticated because she wanted to vary her style of writing and she also tries to keep the same theme of a dominating person and a weak person. She tries to paint the setting of her poem in the readers mind with the style of her writing. She also uses rhyming couplets in her poems. Her ability to do is excellent. I also think that these poems were written for pure enjoyment of reading and not taking it apart and look closely at each and every word, then comment on it. The poem You Will Be Hearing From Us Shortly can be looked at in two different views. The first is already mentioned above and then the second way of looking at it is the comic way. Maybe it wasnt meant to be real but just a pure fantasy where as Half-Past Two was meant to be real as all of the children would go through that stage when they are young. The ideas shown in the poems are quite different but in saying that they always have a good person and a bad person and the idea of them two always being at war. I think that U A Fanthorpe has successfully achieved her goal of creating sympathy to the disempowered people. After studying about her and her poems I have learned that powerful writing can be anything from structure of the poem to the vocabulary used, it does not necessarily mean strong language or words. I agree with some of her views but not all of them, I agree particularly with Half Past Twos views as I have been through that stage and know the feeling.

Worldview God Ultimate Reality Knowledge Religion Essay

Worldview God Ultimate Reality Knowledge Religion Essay Believers coming from their respective faiths are so diverse whether some share the same religion or if they are in completely different religions. For this reason, there is a great importance for believers to understand that everyone has a worldview. A worldview is considered to be a set of assumptions about reality, generally unconsciously held, that can affect how we think and how we live (Cosgrove, 2006, p. 24-25). The set of assumptions are important beliefs that depend highly on the person who perceives a worldview. With this in mind, theology, ultimate reality, and knowledge are important beliefs that are most critical to the formation of my worldview. As a Catholic, theology takes a similar importance and influence of my beliefs with Christianity. In fact, the Christian doctrine of the Trinity is what as a Catholic I strongly rely on. As the father, He is the creator of everything. The second branch of the Trinity characterizes Him as the son. God lived as Jesus. His mother was destined to be Mary. Jesus was then created through the Holy Spirit, which is the final part of the Trinity. When Jesus faced Resurrection, he remained on earth for a few days and later went up to heaven (BBC, 2009). He promised all of his followers that his Spirit would guide them forever. The presence of Jesus provides me enough physical evidence to assume that he was God at the same time. Furthermore, Gods character can be best viewed according to His personality traits. First of all, He is knowable (Who is God, n.d.). God opens His heart and doors to us. We can know Him in a confidential way. He is approachable (Who is God, n.d.). God invites us to communicate with Him. He is the best listener whenever we feel anything that is troubling us. God is creative (Who is God, n.d.). We are able to use the previous materials that He has left for us to resolve our own problems. God is forgiving (Who is God, n.d.). He punishes those who sin; however, He is willing to forgive us if we go back and form a relationship with Him. God is honest (Who is God, n.d.). Anything God says will be efficient and said with honesty. The difference between humanity and God is that He is always honest. We can take His word to all the promises He makes to us. Also, God is capable (Who is God, n.d.). He is capable to understand us under any condition. Ultimate reality is another belief that strongly ties with God and my worldview. God is the ultimate creator of reality.   Humanity understands and recognizes the existence of reality.   The existence of the past is a guide for humanitys present life.   There exists a beginning and an end to humanity when interpreting time.   The bad or sinful actions committed by humanity are considered evil.   Humanity does not possess evil but may decide depending on the actions performed.   There exists good in reality. The supernatural realm equals Gods nature, which is his love (The Supernatural, 2009). According to Gods realm, He is interacting and preparing us until the day arrives where we will confront and recognize Him without any barriers. Theology and ultimate reality are two types of beliefs that I strongly depend on, but epistemology is the final belief identifying what I know about God. Through revelation, we are able to recognize God. There are two types of knowledge. They are empirical and absolute knowledge (Valea, 2009). God created everything without evil. Particularly, humanity was created in Gods personal image (Genesis 1:27-28). He created our senses under empirical knowledge to use actual facts from nature. The mind was created to make judgments (Valea, 2009). He gave us the senses to trust in them and the mind to understand the world revolving around us. God made a realistic approach of connecting nature with humans. Absolute knowledge, which is defined as knowing God, is not intended to counteract empirical knowledge, but the intention is to complete it (Valea, 2009). This means a connection with God goes beyond the mind. Without becoming disrupted, the mind functions according with Faith. After all, to be able to have a worldview one must have beliefs according to the persons faith. We are all unique with our own perspective about what major beliefs formulate each of our own worldview. In my case, God, human nature, and epistemology are the three major beliefs that compose my worldview.

The French Revolutionary War of 1848 Essay -- French Revolution of 184

The numerous revolutions and uprisings that took place in Europe at the beginning of the eighteenth century signified the onset of more than a few liberalistic revolutions that shaped this continent’s governance to this date. This revolutionary wave was very significant, as it marked the collapse of traditional authorities and the establishment of more political and democratic forms of government. This year 1848; has been recognized by many as the ‘year of revolution’ because of the great number of political revolutions that took place allover Europe at this time. These 1884 revolutions started of in the French republic before spreading out to the other Western European nations. The 1884 revolutions were very significant to the French republic given the fact through them, the Orleans kingdom authority over France came to an end and the second French republic was born. The 1884 revolutionary war in France was motivated by factors like a disapproval of the political leadership, widespread ideology of nationalism across Europe, and a greater demand for democracy among others. This war lasted only for less than five years, with several thousands of people dead and other thousands being forced into exile. This paper gives a discussion of the origins and causes of these 1848 revolutionary wars in France. History of France Before 1848 1. Ancient France The French nation is thought to have been founded at around 297 AD when the Salian Franks were given the authority to settle in the region occupied by the Batavians, a Germanic tribe during the era of the Gallic wars. The first king from the historical information was Clodio who began his reign at around 426 AD. However, it was not until the early nineteenth century that Franc... ...48: Revolution and Reform. New York, NY: Berghahn Books, 2001. Fortescue, William. France and 1848: The End of Monarchy. Abingdon, Oxiford: Routledge, 2005. Hessels, John. Lex Salica: The Ten Texts with the Glosses, and the Lex Emendata. London: Adamant Media, 2005. Merriman, John. A History of Modern Europe: from the Renaissance to the present, 3rd edition. New York, NY: W.W. Norton, 2010. Rao, Raghavendra. History of Modern Europe Ad 1789-2002. New York, NY: Sterling Publishers Pvt, 2005. Roberts, Williams. France: A Reference Guide from the Renaissance to the Present. New York, NY: Infobase Publishing, 2004. Sperber, Jonathan. The European Revolutions, 1848-1851. New York, NY: Cambridge University Press, 2005. Winders, James. European Culture since 1848: From Modern to Postmodern and Beyond. Sydney, NSW: Palgrave Macmillan, 2001.

Terrorists and Personal Weapons :: Terrorism

Terrorists and Personal Weapons Personal weapons fired at short ranges are the primary weapons of terrorists as well as the police officer or soldier fighting against them. One of the most important facets of personal weapons is that they have changed little since the 1940s. They have not been affected by the technological revolutions of nuclear, electronic and aerodynamic guidance and control systems. The weapons may be smaller and lighter with more advanced sights, but the ranges and rates of fire have changed little. The most significant change in personal weapons is most likely the controlled burst. The controlled burst is a system of sustained fire where bullets are fired in short, fast groupings of three. These three round bursts conserve ammunition and also give more effective fire for normal use. Another important development with the ammunition is the creation and use of caseless ammunition, which eliminates the need to eject a cartridge. Plastic ammunition has been designed primarily for training but could be effective for terrorists. If a gun made up completely of non-metallic parts, then plastic bullets would be desirable in evading detection at airports. While some terrorists employ the use of assault rifles, light-machine guns, sub-machine guns and even shotguns, the pistol is still the most popular. Revolvers and self-loading pistols are used because of their size and ease of concealment. Pistols can be carried in a pocket or a hip or shoulder holster, leaving both hands free until it becomes necessary to draw the gun. Armor-piercing missiles are used increasingly on attacks of both armored vehicles and the walls of buildings. They have had little success against vehicles, however, because they do not usually achieve a clean hit at the right angle in the right place, which is essential for effectiveness. Arab terrorists use the hand-held surface-to-surface Russian RPG 7 missile most commonly, and oftentimes these weapons have been largely provided to Arab governments who then can pass them on to terrorists. Terrorists can also use mortars in their attacks. Improvised mortars are extremely easy to make but can be inaccurate and unreliable, and so accidents are unavoidable. Most suitable for terrorist use are light mortars. A popular light mortar is the British 51mm Mortar, which weighs 6.25 kilograms and (its bomb weighs only 0.9kg). It has a range of 800 meters and a projected error of 2%. The use of anti-aircraft missiles by guerrillas to shoot down helicopters and other aircraft has increased.

Vietnam After the Vietnam War :: Vietnam War Essays

The new unified Vietnam became the Socialist Republic of Vietnam (SRV). With the Americans gone, however, Vietnam's military problems were not over. In neighboring Kampuchea (previously named Cambodia), Pol Pot and the Khmer Rouge began a reign of terror in hopes of creating a pre-industrial utopia, murdering around 2 million people in so-called "killing fields." In 1978, the SRV invaded Kampuchea to stop the Khmer Rouge, in what became known as "Vietnam's Vietnam." While the invasion put an end to the "killing fields," China became upset by the SRV's extension of influence in the region and began a border war with Vietnam. After decades of war, Vietnam found itself with the world's fourth largest army but one of the poorest economies. In the late 1980s and early 1990s, it began to turn more and more to capitalism and a liberal economy. By 1975, Vietnam was off the Gallup Poll list of top issues in the US. Outside of concern for remaining POWs still in Vietnam, Americans became less and less concerned with events in the country. Nonetheless, the war had lasting impacts. It inspired a public distrust of the US government and made the military less popular, at least in the short term. The draft has not been used since. President Reagan tried to follow the Weinberger Doctrine, "No More Vietnams." In 1982, Yale student Maya Ying Lin's design for the Vietnam War Memorial was built in Washington DC, a permanent monument to the American casualties of the war. Another monument to the Vietnam War is the role it continues to play in American popular culture. Angels from Hell (1968), Satan's Sadists (1969), Chrome and Hot Leather (1971), The Losers (1971), and Taxi Driver (1976) deal with Vietnam veterans' difficulties with life after returning to the US. Tracks (1976), Who'll Stop the Rain (1978), Between Heaven and Earth (1994), and The War (1994) deal also deal with veterans scarred by the war. Other films such as Coming Home (1978), The Deer Hunter (1978), and Born on the Fourth of July(1989) depict veterans' mostly successful struggles to cope with life after the war. Apocalypse Now (1979) made officers villains, but An Officer and a Gentleman (1982), Lords of Discipline (1983), Taps(1981), and Private Benjamin (1980) portrayed the military involved in Vietnam more positively. From Rambo (1982) to Platoon (1986) to Full Metal Jacket (1987), movie depictions of the Vietnam experience have varied a great deal.

Law of Increasing Cost Essay

The three types of unemployment are Structural, Frictional and Cyclical Unemployment. Structural unemployment occurs due to the disparity between the skills of a person whose looking for a job and the skills needed for the jobs available thus, the job seeker’s profession or skills is not likely related to that line of work. Frictional Unemployment is another type of unemployment which is strongly related to structural unemployment as the two both depends on the dynamics changes in the economy. Thus, the people who do not even have work may not accept the first job offered to them because of the skills needed for the job and the salary. On the other hand, Cyclical Unemployment is due to lack of demand for work and is attributed to economic contraction. Cyclical Unemployment- the Government should implement and fund a program where in poorer and jobless people with capability can be able to have their own job and receive necessary payment. In doing such thing they can be able to increase productivity and economic efficiency as well as the workers welfare. Answer to question no. The Law of Increasing Cost states that as the Marginal Cost, say X, increases the Cost of the Product, say Y, decreases and vice versa. Thus, the cost of product is dependent and inversely proportional on the marginal cost of that product. Cost of Product (Y) Marginal Cost (X) Answer to question no. 5 A progressive tax is the rate of the taxes that increases as the tax payers’ income increases. The system defends on the percentage of income of an individual. Those high-income people should pay higher percentage of tax than those low-income people. An example of progressive tax is a Graduated Tax. The general sales is said to be regressive because everyone including the rich and the poor utilize it and therefore has to buy goods in order to survive for example clothes, the poor pay more of the percentage of the sales (clothes) tax compare to the rich people, that is why it is regressive. Answer to question no. 6 Inflation hurt the rich and much more the poor people. In order for the rich to uphold their ways of living they are tend to pay much greater price for the goods and services. In a worse case, the poor may not be able to afford those goods and services, thus it posses a threat to their family and to the economy in general. On the other, economist may benefit from inflation since they can somehow predict inflation rate and thus, make appropriate preparations. Answer to question no. 8 Public Good are goods and services that are available for everyone to consume. Also, consumption of these goods does not decrease the availability of the supply. Such good includes information goods and human rights. On the other hand, a private market offers goods that are the exact different of public goods, goods that are good for only one consumption and is for everyone to consume. Thus, the main reason why the public market cannot offer public goods is because public goods are free and the private market, more or less, does not offer free items. Answer to question no. 9 Full employment is define as the state and condition of the national economy, where all of the job seekers are willingly accept the job offers to them regardless of the amount of wages they are about to earn as well as the working conditions. It clearly indicates 0% of people who do not have job or unemployed. Answer to question no. 10 No. It is the objective of the public market to increase revenue and thus, it important to give greater attention to the benefits that the firm will have rather than that of the society. Because positive externalities mean that the society will gain greater benefit than that of the firm, it is likely that the public market will not be able to produce the socially optimal amount of good that is characterize by positive externalities.

Merck Case

Pharmaceuticals: Merck Sustaining Long-term Advantage Through Information Technology Hiroshi Amari Working Paper No. 161 Working Paper Series Center on Japanese Economy and Business Columbia Business School December 1998 Columbia-Yale Project: Use of Software to Achieve Competitive Advantage PHARMACEUTICALS: MERCK Sustaining Long-term Advantage Through Information Technology Prepared by Hiroshi Amari Research Associate, Yale University William V. Rapp and Hugh T. Patrick Co-principal Project InvestigatorsCenter for International and Area Studies Yale University New Haven, CT 06520 203-432-9395 (Fax: 5963) e-mail: william. [email  protected] edu Revised December 1998 Table of Contents 1. Introduction: Objective of this Study 2. The Pharmaceutical Industry in a Global Context 3. Product R&D and Clinical Trials 4. Manufacturing and Process R&D 5. Technological Factors Structure-Based Drug (â€Å"Rational Drug†) Design Structure-Based Drug (â€Å"Rational Drug†) Design 6. Merck 7. Managerial Decision Making 8. Decision Making on IT projects 9. Joint Ventures 10. Information Technology and Organization 11.Appendix I – Summary Answers to Questions for Merck – Strategy & Operations 12. Appendix II – INDUSTRY AND FIRM BUSINESS DATA 13. Bibliography 2 Introduction: Objective of this Study This case study of Merck was completed under a three year research grant from the Sloan Foundation. The project's purpose is to examine in a series of case studies how U. S. and Japanese firms who are recognized leaders in using information technology to achieve long-term sustainable advantage have organized and managed this process. While each case is complete in itself, each is part of this larger study. This pharmaceutical industry case together with other cases2 support an initial research hypothesis that leading software users in both the U. S. and Japan are very sophisticated in the ways they have integrated software into their management stra tegies and use it to institutionalize organizational strengths and capture tacit knowledge on an iterative basis. In Japan this strategy has involved heavy reliance on customized and semicustomized software (Rapp 1995) but is changing towards a more selective use of package software managed via customized systems. In turn, U. S. ounterparts, such as Merck, who have often relied more on packaged software, are doing more customization, especially for systems needed to integrate software packages into something more closely linked with their business strategies, markets, and organizational structure. Thus, coming from different directions, there appears some convergence in approach by these leading software users. The cases thus confirm what some other analysts have hypothesized, a coherent business strategy is a necessary condition for a successful information technology strategy (Wold and Shriver 1993). These strategic links for Merck are presented in the following case. Industries a nd firms examined are food retailing (Ito-Yokado and H. Butts), semiconductors (NEC and AMD), pharmaceuticals (Takeda and Merck), retail banking (Sanwa and Citibank), investment banking (Nomura and Credit Suisse First Boston), life insurance (Meiji and USAA), autos (Toyota), steel (mini-mills and integrated mills, Nippon Steel, Tokyo Steel and Nucor), and apparel retailing (WalMart). The case writer and the research team wish to express their appreciation to the Alfred P.Sloan Foundation for making this work possible and to the Sloan industry centers for their invaluable assistance. They especially appreciate the time and guidance given by the center for research on pharmaceuticals at MTT as well as Mr. Sato at Takeda. This refers to cases for which interviews have been completed. See footnote 3. These and other summary results are presented in another Center on Japanese Economy and Business working paper: William V. Rapp, â€Å"Gaining and Sustaining Long-term Advantage Through In formation Technology: The Emergence of Controlled Production,† December 1998 strategy (Wold and Shriver 1993). 3 These strategic links for Merck are presented in the following case. Yet this case along with the other cases also illustrates that implementation and design of each company's software and software strategy is unique to its competitive situation, industry and strategic objectives. These factors influence how they choose between packaged and customized software options for achieving specific goals and how they measure their success.Indeed, as part of their strategic integration, Merck and the other leading software users interviewed have linked their software strategies with their overall management goals through clear mission statements that explicitly note the importance of information technology to firm success. They have coupled this with active CIO (Chief Information Officer) and IT (information technology) support group participation in the firm's business and decision making structure.Thus for firms like Merck the totally independent MIS (Management Information Systems) department is a thing of the past. This may be one reason why outsourcing for them has not been a real option, though their successful business performance is not based solely on software. Rather as shall be described below software is an integral element of their overall management strategy and plays a key role in serving corporate goals such as enhancing productivity, improving inventory management or strengthening customer relations.These systems thus must be coupled with an appropriate approach to manufacturing, R, and marketing reflecting Merck's clear understanding of their business, their industry and their firm's competitive strengths within this context. This clear business vision has enabled them to select, develop and use the software they require for each business function and to integrate these into a total support system for their operations to achieve corpo rate objectives. Since this vision impacts other corporateThese and other summary results are presented in another Center on Japanese Economy and Business working paper: William V. Rapp, â€Å"Gaining and Sustaining Long-term Advantage Through Information Technology: The Emergence of Controlled Production,† December 1998 3 4 decisions, they have good human resource and financial characteristics too (Appendix I & ii). Yet Merck does share some common themes with other leading software users such as the creation of large proprietary interactive databases that promote automatic feedback between various stages and/or players in the production, delivery and consumption process.Their ability to use IT to reduce inventories and improve control of the production process are also common to other leading software users. They are also able organizationally and competitively to build beneficial feedback cycles or loops that increase productivity in areas as different as R, design and man ufacturing while reducing cycle times and defects or integrating production and delivery. Improved cycle times reduce costs but increase the reliability of forecasts since they need to cover a shorter period.Customer satisfaction and lower inventories are improved through on-time delivery. Thus, software inputs are critical factors in Merck's and other leading users' overall business strategies with strong positive competitive implications for doing it successfully and potentially negative implications for competitors. An important consideration in this respect is the possible emergence of a new strategic manufacturing paradigm in which Merck is probably a leading participant.In the same way mass production dramatically improved on craft production through the economies of large scale plants that produced and used standardized parts and lean production improved on mass production through making the production line more continuous, reducing inventories and tying production more close ly to actual demand, what might be called â€Å"controlled† production seems to significantly improve productivity through monitoring, controlling and linking every aspect of producing and delivering a product or service including after sales service and repair.Such controlled production is only possible by actively using information technology and software systems to continuously provide the monitoring and control function to what had previously been a rather automatic system response to changes in 5 expected or actual consumer demand. This may be why their skillful use of information technology is seen by themselves and industry analysts as important to their business success, but only when it is integrated with the business from both an operation and organization standpoint reflecting their overall business strategy and clarity of competitive vision.Therefore at Merck the software and systems development people are part of the decision making structure while the system its elf is an integral part of organizing, delivering and supporting its drug pipeline from R through to sales post FDA approval. This sequence is particularly critical in pharmaceuticals where even after clinical trials there is a continuous need to monitor potential side effects. Therefore Seagate Technology may be correct for Merck too when they state in their 1997 Annual Report â€Å"We are experiencing a new industrial revolution, one more powerful than any before it.In this emerging digital world of the Third Millennium, the new currency will be information. How we harness it will mean the difference between success and failure, between having competitive advantage and being an also-ran. † In Merck's case, as with the other leading software users examined, the key to using software successfully is to develop a mix of packaged and customized software that supports their business strategies and differentiates them from competitors. However, they have not tried to adapt their organizational structure to the software.Given this perspective, functional and market gains have justified the additional expense incurred through customization, including the related costs of integrating customized and packaged software into a single information system. They do this by assessing the possible business uses of software organizationally and operationally and especially its role in enhancing their core competencies. While they will use systems used by competitors if there is no business advantage to developing their own, they reject the view that information systems are generic products best developed by outside vendors who can achieve low cost through economies of scale and who can more easily afford to invest in the latest technologies. 4 In undertaking this and the other case studies, the project team sought to answer certain key questions while still recognizing firm, country and industry differences. These have been explained in the summary paper referenced in fo otnote 3. We have set them forth in Appendix I where Merck's profile is presented based on our interviews and other research.Readers who wish to assess for themselves the way Merck's strategies and approaches to using information technology address these issues may wish to review Appendix I prior to reading the case. For others it may be a useful summary. 5 Merck and the other cases have been developed using a common methodology that examines cross national pairs of firms in key industries. In principle, each pair of case studies focuses on a Japanese and American firm in an industry where software is a significant and successful input into competitive performance.The firms examined are ones recognized by the Sloan industry centers and by the industry as ones using software successfully . To develop the studies, we combined analysis of existing research results with questionnaires and direct interviews. Further, to relate these materials to previous work as well as the expertise loc ated in each industry center, we held working meetings with each center and coupled new questionnaires with the materials used in the previous study to either update or obtain a questionnaire similar to the one used in the 1993-95 research (Rapp 1995).This method enabled us to relate each candidate and industry to earlier results. We also worked with the industry centers to develop a set of questions that specifically relate to a firm's business strategy and software's role within that. Some questions address issues that appear relatively general across industries such as inventory control. Others such as managing the drug pipeline are more specific to a particular industry. The focus has been to establish the firm's perception of its industry and its competitive position as well as its advantage in developing and using a software strategy.The team also contacted customers, competitors, and industry analysts to determine whether competitive benefits or impacts perceived by the firm were recognized outside the organization. These sources provided additional data on measures of competitiveness as well as industry strategies and structure. The case studies are thus based on extensive interviews by the project team on software's use and integration into management strategies to improve competitiveness in specific industries, augmenting existing data on industry dynamics,firmorganizational structure and management strategy collected from the Sloan industry enters.In addition, we gathered data from outside sources andfirmsor organizations with which we worked in the earlier project. Finally, the US and Japanese companies in each industry that were selected on the basis of being perceived as successfully using software in a key role in their competitive strategies in fact saw their use of software in this exact manner while these competitive benefits were generally confirmed after further research.The questions are broken into the following categories: General Manage ment and Corporate Strategy, Industry Related Issues, Competition, Country Related Issues, IT Strategy, IT Operations, Human Resources and Organization, Various Metrics such as Inventory Control, Cycle Times and Cost Reduction, andfinallysome Conclusions and Results.They cover a range of issuesfromdirect use of software to achieve competitive advantage, to corporate strategy, to criteria for selecting software, to industry economics, to measures of success, to organizational integration, to beneficial loops, to training and institutional dynamics, andfinallyto interindustry comparisons. 7 The Pharmaceutical Industry in a Global Context In advanced countries that represent Merck's primary market, the pharmaceutical industry is an exceptionally research intensive industry where many firms are large multinationals (MNCs).It is also heavily regulated for both local producers and MNCs. Regulations work as both constraints and performance boosters since drugs are used with other medical a nd healthcare services. Therefore, healthcare expenditures are divided among many industries and providers of which pharmaceuticals are only one. All parties involved are interested in influencing the regulatory environment and in participating in the growth in healthcare services. This means understanding the industry requires appreciating its political economic context.In this regard, healthcare providers in rich nations are currently under pressure to control costs due to aging populations. Regulators who have the authority to change the demand structure through laws and regulations are considering various measures to reduce costs such as generic drug substitution which may mean lower returns for discovering and developing drugs. Still, if drugs are more effective at reducing healthcare costs compared to other treatments, Pharmaceutical companies can benefit.Since R is at the heart of competition, each drug company must respond to these cost containment pressures cautiously and s trategically in competing for healthcare expenditures. Another important aspect of this industry is technological change arising from the convergence of life and biological sciences. Many disciplines now work together to uncover the mechanisms that lie behind our bodies and various diseases. Examples are molecular biology, cell biology, biophysics, genetics, evolutionary biology, and bioinformatics.As scientists see life from these new chemical and physical viewpoints, the ability to represent, process and organize the massive data based on these theories becomes critical. Because computers are very flexible scientific instruments (Rosenberg 1994), progress in information technology and computer science has broadened scientific frontiers for the life and biological sciences. These advances have opened new doors to 8 attack more complex diseases, including some chronic diseases of old age.These therapeutic areas are present opportunities for pharmaceutical companies since they addres s demographic and technical changes in advanced countries. Still, to take advantage of these opportunities requires information technology capabilities. Historically, the drug industry has been relatively stable where the big players have remained unchanged for years. This has been due to various entry barriers such as R costs, advertising expense, and strong expertise in managing clinical trials. It is difficult and expensive for a new company to acquire this combination of skills quickly.However, there are signs the industry and required mix of skills may be changing. There have been several cross national mergers especially between U. S. and European companies. In addition, new biotechnology companies are very good at basic research, which may force pharmaceutical R to transform itself. For example, no single company even among the new mega-companies is large enough to cover all new areas of expertise and therapeutic initiatives. Thus, many competitors have had to form strategic alliances to learn or access new technologies and to capture new markets. Conversely, a stand-alone company can have a lot to lose.The challenge facing large pharmaceutical companies is how fast and how effectively they can move to foster both technological innovation and cost containment without exposing themselves to too much risk. The pharmaceutical industry in all of Merck's major markets reflects these cost containment pressures, the need to harmonize expensive and time consuming clinical trials, and the impact of extensive regulations. Information technology has had its impacts too. For example, to respond to these challenges Merck is using more management techniques based on consensus decision making among top functional managers.This requires better communication support using e-mail and groupware combined with face-to-face communication. This is part of an industry trend towards greater parallel decision making in R&D and less sequential decision making where A must first c oncur on a project before moving to B, etc Now all elements of the firm evaluate the project simultaneously at each 9 stage. In this manner, Merck has significantly reduced coordination costs while centralizing and speeding the overall decision making process. Additionally, first-tier irms have had to follow a trend in R&D strategies that increasingly use information technologies. Exchange of data and ideas across national borders has become relatively easy, and contracts may specify access to another company's database. Because many companies share similar R instruments and methods, one company's instruments may be compatible with other companies'. Indeed, the trend towards greater use of Web-based technology in R and other operations may change our notion of a firm and its boundaries. Firms may eventually be characterized by knowledge creating capabilities (Nonaka and Takeuchi 1995).Having more ways to communicate with other companies makes frequent communication with greater nuan ce possible. This supports the trend towards more strategic alliances unless overtaken by the creation of larger firms through continued mergers. This is also partially due to the nature of the industry which is part of the fine chemical industry where changes in technologies are rapid and often discontinuous. It therefore requires different management skills from other technology based industries, especially as the knowledge required for innovation tends to be more specialized thus demanding less coordination than assembly industries.Transferring mass production know-how to R is also limited. Still, the U. S. and European industries have been undergoing massive reorganization to achieve economies of scope and scale in R and marketing where firms are taking advantage of the fact that the U. S. industry is much less regulated than most foreign industries (Bogner and Thomas 1996). The U. S. companies grew after World War II due to a huge home market combined with the global market for antibiotics this was before British firms began to recapture market share.At that time, European firms did not have the resources to sell drugs directly to U. S. doctors. The European recovery period gave U. S. firms enough time to take advantage of antibiotics. Then, when the U. S. market became saturated, U. S. 10 firms expanded into global markets in the early 1960s. This forced U. S. firms to diversify their R as well. At the same time, in 1962 amendments to the Food, Drug and Cosmetic Act increased the rigor of drug regulation creating an entry barrier to industry R that favored large established firms (Bogner and Thomas 1996).The U. S. effectively tightened their regulations after their industry had acquired sufficient R skills and resources. This timing seems to account for today's industry success. Another factor is that unlike the European industry, U. S. firms had few incentives to integrate vertically. During the War the military distributed antibiotics. Therefore, the U . S. firms were generally bulk chemical producers such as Merck and Phizer or sellers of branded drugs such as Abbott and Upjohn. At the end of the War, only a few firms such as Squibb were fully integrated.However, as promotion and other downstream functions became more critical, controlling functions such as distribution became a strategic objective. To accomplish this they acquired other firms (Merck acquired Sharpe and Dohine and Phizer acquired Roerig), developing expansion via merger and acquisition as a business strategy and core competency. This helped lay the foundation for subsequent industry consolidation. Today, American healthcare is based on the belief that while making progress in science is the best way to solve medical problems, cost containment is also important.As a result, while American healthcare is the most expensive in the world, it is also not available to everyone and is the most subject to cost scrutiny. Indeed, since drugs are just one way to improve heal th, consumers should want to remain healthy and choose cost effective means to do this. However, the reality is that insurance systems covering different services give incentives and disincentives for particular care (Schweitzer 1997). Thus, coordinated adjustment of prices for healthcare is necessary to get markets for healthcare products to work better. In the U. S. , this has led to a public policy push for HMOs.These healthcare purchasers have in turn set the reward schemes available to healthcare providers such as pharmaceutical companies so as to reduce transaction costs (Ikegami and Campbell 1996) 11 and promote innovation. These developments and trends are putting more pressure on major firms to put more resources into R&D, to focus more critically on just ethical drug development for the global market, and to be more careful in gathering information on clinical trials and side effects. The most important market for Merck in this regard is the U. S. where NTH has pursued a u nified approach.This is because the NIH (The National Institutes of Health) has actively supported basic life science research in U. S. universities, especially after World War II. NSF (National Science Foundation) also encouraged collaboration between academia and industry with partial funding by the government. Other federal and state funding has been important to the scientific community as well, especially in biotechnology. In biotechnology, the funding of basic research has led to a complex pattern of university-industry interaction that includes gene patenting and the immediate publishing of results (Rabinow 1996).U. S. drug companies are of course profit motivated but are regulated by the FDA (Federal Drug Administration) which is rigorous about its drug approvals, demanding clear scientific evidence in clinical research as its operation is basically science oriented. Product R&D and Clinical Trials Still, despite this R&D support, industry economics are driven by pharmaceuti cal R&D's very lengthy process, composed of discovering, developing and bringing to market new ethical drugs with the latter heavily determined by the drug approval process in major markets such as the U.S. , Europe and Japan6. These new therapeutic ethical products fall into four broad categories (U. S. Congress, OTA 1993): one, new chemical entities (NCEs) – new therapeutic entities (NTEs) – new therapeutic molecular compounds never before used or tested in humans; two, drug delivery mechanisms – new approaches to delivering therapeutic agents at the desired dose to the desired part of the body; three, 6 Ethical drugs are biological and medicinal chemicals advertised and promoted primarily to the medical, pharmacy, and allied professions.Ethical drugs include products available only by prescription as well as some over-the-counter drugs (Pharmaceutical Manufacturers Association 1970-1991). 12 next stage products – new combinations, formulations, dosing forms, or dosing strengths of existing compounds that must be tested in humans before market introduction; four, generic products – copies of drugs not protected by patents or other exclusive marketing rights. From the viewpoint of major pharmaceutical firms such as Merck, NCEs are the most important for the R of innovative drugs that drive industry success.Since it is a risky and very expensive process, understanding a company's R&D and drug approval process is critical to understanding the firm's strategy and competitiveness both domestically and globally. Statistics indicate that only about 1 in 60,000 compounds synthesized by laboratories can be regarded as â€Å"highly successful† (U. S. Congress, OTA 1993). Thus, it is very important to stop the R process whenever one recognizes success is not likely.Chemists and biologists used to decide which drugs to pursue, but R is now more systematic and is a collective company decision since it can involve expenditures of $250 to $350 million prior to market launch, thus the need for more parallel decision making. Key factors in the decision making process are expected costs and returns, the behavior of competitors, liability concerns, and possible future government policy changes (Schweitzer 1997). Therefore, stage reviews during drug R are common, and past experiences in development, manufacturing, regulatory approvals, and marketing can provide ample guidance.NCE's are discovered either through screening existing compounds or designing new molecules. Once synthesized, they go through a rigorous testing process. Their pharmacological activity, therapeutic promise, and toxicity are tested using isolated cell cultures and animals as well as computer models. It is then modified to a related compound to optimize its pharmacological activity with fewer undesirable biological properties (U. S. Congress, OTA 1993). Once preclinical studies are completed and the NCE has been proven safe on animals, the dru g sponsor applies for Investigational New Drug (IND) status.If it receives approval, it starts Phase I clinical trials to establish the 13 tolerance of healthy human subjects at different doses to study pharmacological effects on humans in anticipated dosage levels. It also studies its absorption, distribution, metabolism, and excretion patterns. This stage requires careful supervision since one does not know if the drug is safe on humans. During phase II clinical trials a relatively small number of patients participate in controlled trials of the compound's potential usefulness and short term risks.Phase III trials gather precise information on the drug's effectiveness for specific indications, determine whether it produces a broader range of adverse effects than those exhibited in the smaller phase I and II trials. Phase III trials can involve several hundred to several thousand subjects and are extremely expensive. Stage reviews occur before and during each phase, and drug develo pment may be terminated at any point in the pipeline if the risk of failure and the added cost needed to prove effectiveness outweigh the weighted probability of success.There is a data and safety monitoring board in the U. S.. This group has access to â€Å"unblinded data† throughout the conduct of a trial but does not let anyone else know what the data shows until it is necessary. For example, they will not divulge the efficacy data until the trial reaches a point where it seems appropriate to recommend stopping it because the null hypothesis of efficacy has been accepted or rejected. The FDA will usually insist on the drug proving efficacy with respect to ameliorating a disease before giving approval.If clinical trials are successful, the sponsor seeks FDA marketing approval by submitting a New Drug Application (NDA). If approved, the drug can be marketed immediately, though the FDA often requires some amendments before marketing can proceed (Schweitzer 1997). However, suc cessful drug development and sales not only requires approval of therapeutic value and validity but also that the manufacturing process meet stringent â€Å"best-practice† standards. To meet U. S. regulations, Phase IV trials are required. Manufacturers selling drugs must notify the FDA periodically about the 14 erformance of their products. This surveillance is designed to detect uncommon, yet serious, adverse reactions typically not revealed during premarket testing. This postapproval process is especially important when phase III trials were completed under smaller fast track reviews. These additional studies usually include use by children or by those using multiple drugs where potential interactions can be important (Schweitzer 1997). Furthermore, because drug development costs are so high relative to production costs, patent protection is another key aspect of a company's management strategy. Under U. S. aw, one must apply for a patent within one year of developing an N CE or the innovation enters the public domain. Therefore, patenting is usually early in the development cycle or prior to filing the NCE. But as this begins the patent life, shortening the approval period extends a drug's effective revenue life under patent. This makes managing clinical trials and the approval process an important strategic variable. Although creating a drug pipeline through various stages of development is relatively standardized, it is changing as companies use different methods to reduce time and related costs of new drug development.Companies are constantly pressuring the authorities to reduce NDA review times. As a consequence, the FDA did introduce an accelerated approval process for new drugs in oncology, HIV (AIDS) and other life threatening illnesses. A familiar feature of this new fast track review is the use of surrogate end points, or proxies for clinical end points which are measured by laboratory values but lack supporting clinical outcomes data. Accel erated approval speeds new drugs to market saving companies tens of millions of dollars in negative cash flow.However, it does not generate clinical values that insurers and managed care organizations demand. Countering this situation is thus the trend among drug firms to increase the complexity of their analyses during clinical trials. Companies have begun to use cost-effective analysis in their evaluation of new drugs in assessing competing product development investment alternatives and by integrating cost effectiveness analysis into their clinical trials. They also try to capture quality of life 15 measures such as how patients perceive their lives while using the new drug.Companies vary their analysis by country (Rettig 1997) since measures of effectiveness shift according to clinical practice, accessibility to doctors, and what different cultures value as important. There are no universal measures of the quality of life. At present, the components measured depend largely on th e objectives of each researcher but some companies are trying to introduce more systematic measures. Nevertheless, no matter what components are chosen for these studies, capturing, storing and using the data requires sophisticated software and data base management techniques which must be correlated with various families of molecules.Also, to avoid the moral hazard of focusing on the weaknesses in a competitor's drug or molecule, some analysts argue companies should examine all domains and their components (Spilker 1996) and move towards agreed performance standards. Furthermore, quality of life measures should only be used when they are of practical use to doctors in treating patients (Levine 1996). Such judgments should be sensitive and informed and should cover criteria related and important to a broad spectrum of patients while balancing measures which can be easily gathered and those that are more complex due to multiple treatments.These trends make clinical trials and data ga thering complex and expensive and put a premium on a firm's ability to manage the process efficiently, including creating and using large patient and treatment databases. Manufacturing and Process R&D The research process differs from production. Yet, both are important, particularly the firm's knowledge of scale-up. This is difficult because production requires uniformity at every stage. Making the average chemical make-up constant is not enough.Careful scale-up is essential to avoid contamination. Variations from the mean in commercial production must be very small. This requires constant control of variables such as the preparation of raw materials, solvents, reaction conditions, and yields. Often, experience will help achieve purer output in the intermediate processes. This better output alleviates problems in later processes. Thus, there is a learning curve in process R which starts at 16 the laboratory. An important distinction is between continuous process and batch process.I n the continuous process, raw materials and sub-raw materials go into a flow process that produces output continuously. This continuous process is more difficult because many parameters and conditions have to be kept constant. This requires a good understanding of both optimizing the chemical process and maintaining safeguards against abnormal conditions. However, continuous processes are less dangerous and require fewer people to control at the site than batch processing where the chemicals are produced in batches, put in pill form and then stored for future distribution and sale (Takeda 1992).The following compares initial process R once a compound is discovered and commercial manufacturing for a representative chemical entity proceeds (Pisano 1996). Comparison research process and commercial production for representative chemical 17 Process R in chemical pharmaceuticals involves three stages: (1) process research, where basic process chemistry (synthetic route) is explored and ch osen; (2) pilot development, where the process is run and refined in an intermediate-scale pilot plant; and (3) technology transfer and startup, where process is run at a commercial manufacturing site (Pisano 1997).Pisano argues that the scientific base of chemistry is more mature than biotechnology and this difference accounts for the more extensive use of computer simulations in drugs made by chemical synthesis than biotechnology-based drugs. Codifying the knowledge in chemistry and chemical engineering in software has a higher explanatory power than in biotechnology. In chemistry, many scientific laws are available for process variables such as pressure, volume, and temperature.Computer models can simulate these in response to given parameters to predict cost, throughput and yield (Pisano 1997). By contrast, biotechnology has aspects that resemble art dependent on an opprator's skill more than science which only requires the proper formulation. This is particularly true for large -scale biotechnology process (Pisano 1997). Simulation is thus less reliably extrapolated to commercial production. An additional factor is the importance of purification after large-scale production in bioreactors in biotechnology-based drugs.It is not rare at this stage of extraction and purification that commercial application becomes impossible, even though the scale-up is successful. Since avoiding contamination is the key in biotechnology-based drugs, extracting and purifying a small amount of the desired materials from a large amount of broth is critical. This process is done using filters, chromatography, and other methods specific to organisms (Koide 1994). Technological Factors All scientific frontiers affect pharmaceutical companies.Since no company can be an expert on everything, what technology to develop in-house and what to license or subcontract have become important issues. In general, pharmaceutical companies were skeptical of new developments in small biotechnolog y firms. Yet the latter now provide new techniques in basic research and fermentation to the MNCs. Other pharmaceutical 18 companies then tend to follow when competitors adopt ideas from less well known biotech companies. This is why many such companies announce platform deals with drug companies to get more financial resources and opportunities.Biotechnology based pharmaceuticals have entered a new development stage which requires the capital, manufacturing and marketing expertise of the large companies. New drug discovery methods and biotechnology each demand skills different from earlier times. Emerging biotech companies offer new ideas and research tools. Other new technologies such as stripping out side effects, specialized drug delivery systems, and â€Å"antisense† which cancels out the disease causing messages of faulty RNA also come from biotechnology (Fortune 1997).These are promising areas of drug research and potential products. Further, these biotech companies de velop new drugs more quickly than large firms. Where they often have difficulty is in managing clinical trials and the approval process, an area where large firms have considerable experience and expertise, including sophisticated software for tracking the large data bases and handling the new computerized application procedure. In addition, biotechnology demands skills in large scale commercial production which smaller startups may not possess.Thus, close association with large firms is logical and efficient, and one should expect more future alliances and joint ventures, though outsourcing to organizations that will manage clinical trials is growing. Another important factor which further encourages specialization in a network of companies is the industry's heavy use of information technology. Indeed, software strategies have become an important part of the industry through their impact on R, drug approval, including clinical trials, and control of manufacturing.If decisions in a science based industry are generally driven by knowledge creation capability dependent on human resources, having information sharing and access mechanisms so complementary capabilities can be efficiently exchanged and used becomes key to successful corporate strategy, especially when that knowledge is growing and becoming increasingly diverse. 19 There is some evidence suggesting when innovation is dependent on trial and error, it is best done when many players try different strategies and are held responsible for the projects they choose (Columbia Engineering Conference on Quality September 1997).If the large drug companies can successfully form principal-agent relationships with biotechnology companies doing advanced research in a particular area in the same way that Japanese parts manufacturers have with large assemblers, there may be opportunities for major breakthroughs without the drug companies having to put such trial and error processes inside the company where they may be less easy to manage. If the make or buy decision in a science based industry is generally driven by knowledge creation capability dependent on human resources, the basis for new product, i. . drug development, becomes more dependent on the nature and facility of information exchange between groups and individuals than asset ownership. Creating information sharing and access mechanisms so that complementary capabilities can be efficiently exchanged and used then becomes the key to successful corporate strategy in knowledge based industries, especially when that knowledge base is growing and becoming increasingly diverse as in the ethical drug industry. Another information sharing issue related to biotech is pharmacology.Classical pharmacology models are often irrelevant for biotech-based drugs. While some proteins express their activities across other species, others can be more species specific. Neither poor results nor good animal trial results need be predictive for humans. Parti cularly difficult problems are those related to toxicology since some animals develop neutralizing antibodies (Harris 1997). Technical support systems are important in biotechnology as well. One is transgenic animals. They provide information on the contribution of particular genes to a disease.This is done by inserting genes that have the function of expressing the phenotype, or interbreeding heterozygotic animals to produce â€Å"knockout animals† that suffer from inherited metabolic diseases. Transgenic animals are relevant to early phase clinical trials since the data from these animals contribute useful data on dose-selection 20 and therapeutic rations in human studies. In addition, they offer hints to which variables are secondary. This simplifies the clinical trial design.In general, significant input in the design and running of phase I and II trials must come from the bench scientists who built the molecule (Harris 1997). Since clinical trials for biotech drugs lack clear guidelines, inhouse communication among drug discovery, preclinical and clinical trials is important, especially due to the increased use of transgenic animals bred to examine inherited diseases. This process in phase I/II trials can be greatly facilitated by information sharing technologies and acts as another driver towards a more integrated approach to decision making using IT.Structure-Based Drug (â€Å"Rational Drug†) Design This is also true of structure-based drug (â€Å"rational drug†) design or molecular modeling which is a range of computerized techniques based on theoretical chemistry methods and experimental data used either to analyze molecules and molecular systems or to predict molecular and biological properties (Cohen 1996). Traditional methods of drug discovery consist of taking a lead structure and developing a chemical program for finding analog molecules exhibiting the desired biological properties in a systematic way. The nitial compounds we re found by chance or random screening. This process involved several trial and error cycles developed by medicinal chemists using their intuition to select a candidate analog for further development. This traditional method has been supplemented by structure-based drug design (Cohen 1996) which tries to use the molecular targets involved in a disorder. The relationship between a drug and its receptor is complex and not completely known. The structure-based ligand design attempts to create a drug that has a good fit with the receptor.This fit is optimized by minimizing the energies of interaction. But, this determination of optimum interaction energy of a ligand in a known receptor site remains difficult. Computer models permit manipulations such as superposition and energy calculation that are difficult with mechanical models. They also provide an exhaustive way to analyze molecules and to save and store this data for later 21 use or after a research chemist has left. However, mode ls must still be tested and used and eventually, chemical intuition is required to analyze the data (Gund 1996).Then the drug must proceed through animal and clinical trials. Still the idea behind this modeling is the principle that a molecule's biological properties are related to its structure. This reflects a better understanding in the 1970s of biochemistry. So rational drug design has also benefited from biotechnology. In the 1970s and 1980s, drug discovery was still grounded in organic chemistry. Now rational drug design provides customized drug design synthesized specifically to activate or inactivate particular physiological mechanisms.This technique is most useful in particular therapeutic areas. For example, histamine receptor knowledge was an area where firms first took advantage of rational design since its underlying mechanism was understood early (Bogner and Thomas 1996). The starting point is the molecular target in the body. So one is working from demand rather than finding a use for a new molecule. The scientific concepts behind this approach have been available for a long time. The existence of receptors and the lock-and-key concepts currently considered in drug design were formulated by P.Ehrlich (1909) and E. Fischer (1894). Its subtleties were understood, though, only in the 1970s with the use of X-ray crystallography to reveal molecular architecture of isolated pure samples of protein targets (Cohen 1996). The first generation of this technology conceived in the 1970s considered molecules as two topological dimensional entities. In 1980s it was used together with quantitative structureactivity relationships (QSAR) concepts. The first generation of this technology has proven to be useful only for the optimization of a given series (Cohen 1996).The second generation of rational drug design has considered the full detailed property of molecules in the three dimensional (3-D) formula. This difference is significant, since numerical parameters in the QSAR approaches do not tell the full story about the interaction between a ligand and a protein (Cohen 1996). 22 This has been facilitated by software and hardware becoming less costly. Thus many scientists are paying attention to computational techniques that are easier to use than mechanical models.This underscores the role of instrumentation in scientific research stressed by Rosenberg (1994). Availability of new instruments, including computers, has opened new opportunities in technological applications and furthered research in new directions. Three dimensional graphics particularly suits the needs of a multi-disciplinary team since everyone has different chemical intuition but appreciates the 3-D image. Rosenberg (1994) notes scientists who move across disciplines bring those concepts and tools to another scientific discipline such as from physics to biology and chemistry.This suggests the importance of sharing instruments, particularly computer images and databases th at help people work and think together. The predominant systems of molecular modeling calculations are UNIX workstations, particularly three dimensional graphics workstations such as those from Silicon Graphics. But other hardware such as desktop Macintoshes and MS-DOS personal computers on the low end and computer servers and supercomputers on the high end have been used. Computational power is required for more complex calculations and this guides the choice of hardware.A variety of commercial software packages are available from $50-$5,000 for PC-based systems to $100,000 or more for supercomputers. Universities, research institutes, and commercial laboratories develop these packages. Still, no one system meets all the molecular modeler's needs. The industry therefore desperately needs an open, high-level programming environment allowing various applications to work together (Gund 1996). This means those who for strategic reasons want to take advantage of this technology must now do their own software development. This is the competitive software compulsion facing many drug producers.In turn, the better they can select systems, develop their capabilities, and manage their use, the more successful they will be in drug development and in managing other aspects of the drug pipeline. 23 The choice of hardware is based on software availability and the performance criteria needed to run it. Current major constraints are the power of graphics programs and the way the chemist interacts with the data and its representation (Hubbard 1996). Apple computers have frequently been used in R because of superior graphics, though this edge may be eroded by new PCs using Pentium MMX as well as moves to more open systems.However, Dr. Popper, Merck's CIO, feels that the real issue, is the software packages for the MAC that research scientists know and rely on but that are not yet available for Windows NT. Thus, MACs continue to be used for Medical R&D which keeps the Windows ma rket from developing. There are, in addition, the elements of inertia, emotional attachment and training which are apparent at major medical schools too. In sum, rational design has opened a wide range of new research based on a firm's understanding of biochemical mechanisms. This means tremendous opportunities to enter new therapeutic areas.However, since rational design is very expensive, it has raised entry costs and the minimum effective size for pharmaceutical firms by putting a premium on those with a sequence of cash generating drugs. It also has favored firms with broader product lines able to spread the costs of equipment over many projects and to transfer knowledge across therapeutic areas, contributing to the increased cost of new drugs through higher R and systems support spending (Bogner and Thomas 1996). A similar analysis applies to the use of other new technologies because major U. S. nd Japanese companies to discover and develop drugs systematically, such as combina torial chemistry, robotic high-throughput screening, advances in medical genetics, and bioinformatics. These technologies affect not only R but also the organization and the way they deal with other organizations as many new technologies are complementary. For example, high-throughput screening automates the screening process to identify compounds for further testing or to optimize the lead compound. Thus, both regulatory and technological change have raised the advantage of developing innovative drugs, even 24 hough it is inherently risky and forces firms to develop better skills in using information technology to support the process. The Pharmaceutical Industry in the United States As explained above, healthcare and the pharmaceutical industry are closely intertwined, especially in the U. S.. Ever since the election of the Clinton Administration, U. S. healthcare has been the focus of heated debate. The pricing of pharmaceuticals in particular is one of the most controversial aspe cts of the industry. Estimates of the cost of bringing a new drug to market are up to over $250 million (DiMasi et. l. 1991). However, once drugs are on the market, the costs of manufacturing, marketing and distribution are relatively small. This loose connection between marginal cost and the market price seems to require further justification for drug pricing. While the obvious answer lies in the high fixed cost of drug development and the expensive and time consuming approval process prior to any positive cash flow, the answer is still not easy. Furthermore, the drug market is very complex for several reasons. First, there are many drug classes for which only a few products exist.Secondly, FDVIOs (health maintenance organizations) and other managed-care plans can negotiate substantial discounts because they are able to control the prescription decisions made by their participating physicians and because they buy in large quantities. These health organizations are highly price sens itive. This means drug prices are substantially determined by the purchaser's demand elasticity. This demand in turn determines investment decisions (Schweitzer 1997). Thirdly, the market for pharmaceuticals is highly segmented, both domestically and internationally, and price discrimination between and within national markets is common.Research studies cannot even agree on a common measure of wholesale price. Indeed, no measure captures actual transaction prices, including discounts and rebates (Schweitzer 1997). Fourth, consumers do not have enough scientific knowledge to assess different drugs. Thus, gatekeepers such as doctors are important (Hirsch 1975). 25 Yet, the current trend is towards managed care and HMOs who closely control costs. This development clearly indicates physicians are losing some autonomy in drug selection. Thus it is not surprising the market share of generic drugs has increased from 15% to over 41% between 1983 and 1996.This has forced the ethical drug man ufacturers to communicate both more effectively with the HMOs and managed care organizations in addition to physicians and to demonstrate the improved efficacy of their products as compared with generics. The acquisition of PBMs (pharmacy benefit managers) by pharmaceutical companies is an important development in this regard. Physicians now have to prescribe drugs available in the formularies of the managed-care organization. PBMs suggest cheaper alternatives to physicians for a given therapeutic benefit to save money.Eighty percent of the 100 million patient/member PBM market as of 1993 is controlled by the five big PBMs (Schweitzer 1997). In turn, when PBMs and mail-order companies expand, the small pharmacies lose the data necessary to examine various drug interactions. Since current U. S. law protects the propriety data of pharmacists and pharmacy chains, information on prescription for those patients who use pharmacies and mail-order companies actually becomes fragmented. It i s likely this development could affect pharmacists' jobs as well. A fifth reason is FDA approval does not mean new drugs are better than old ones.As noted above, this has pressured drug companies to prove the effectiveness in cost and quality of life their drugs bring to patients. Recently, drug companies have often tried to show how their drugs can help patients restore a normal quality of life. As already described, these concerns complicate the design of clinical trials. Consolidation among wholesalers, the greater complexity of clinical trials and globalization favor firms with substantial resources and are part of the reason for the industry's merger trend, especially between U.S. and European companies. The leading pharmaceutical firms ranked by 1994 sales are as follows (Scrip Magazine, Jan. 1996), with five of them the result of cross border mergers. Merck ranks 2d: 26 27 *3: Comparison is based on U. S. dollars *4: Calculation based on the sales of companies before mergers *5: Including OTC (over the counter drugs) *6: Excludes sales through strategic alliances Merck Merck is a multibillion dollar pharmaceutical firm with a long history going back to the 19th century in the U. S. and the 17th century in Germany.While in the past they have diversified into areas like animal health care, they are now very focused almost exclusively on human health, in particular, on ethical branded prescription drugs within human health care since they have found this is their most profitable business area. Also, given the many opportunities that exist, it will demand all their capital and energy for the foreseeable future. It has therefore spun off its animal health care business to a joint venture and sold its specialty chemical business.This strategy and motivation is similar to Takeda's focus on human health, whose market is more lucrative than its other businesses. The company appears to stress their ability to bring innovative drugs to market. Merck briefly tried to produce generic versions of their drugs, but found it was not worth the investment. In addition, they now assume someone else will produce their OTC (over the counter) versions too. This strategic focus is now underscored by their active formation of strategic alliances. For example, in the OTC medicine market in the U. S. nd Europe, but not in Japan, Merck relies on Johnson & Johnson through a joint venture with J to market, distribute and sell the OTC versions of Merck's prescription drugs. This means Merck has seen the OTC market as one way to lengthen the revenue stream for some of its products after their patents expire. In Japan, Merck's agreement is with Chugai Pharmaceutical Co. Ltd. They formed a joint venture in September 1996 to develop and market Merck's OTC medicines there (Merck 1996 Annual Report). Moreover, Merck and Rhone-Poulenc have announced plans to combine their animal health and poultry genetics businesses to form 28Merial, a new company that will be the wo rld's largest in animal health and poultry genetics (Merck 1996 Annual Report). Their primary strategic focus on ethical drugs seems appropriate, but as explained above it is also critical with respect to this strategy that they maintain relationships with those in scientifically related fields. Their work with Rhone-Poulenc must be examined in this light since improving their competence in the genetic business seems a good part of their strategy given developments in biotechnology and the Human Genome Project. This is because biotechnology-related drugs are often species-specific (Harris 1997).More knowledge about the genetic make-up of human and animal bodies may provide some insights into the appropriate choice of animals in pre-clinical trials from which to extrapolate observations to humans. Since this extrapolation is never perfect and you have to do animal experiments anyway, they have added to their competence in genetics via a joint venture with Du Pont called Du Pont-Merck Pharmaceuticals Co, whose investors are E. I. Du Pont (50%) and Merck (50%). This firm has capabilities in fermentation, genetic engineering/rDNA, cell culture, hybridoma, protein engineering, and tissue culture.By forming this alliance, Merck was able to exchange its strengths with Du Pont, an early investor in biotechnology. Du Pont-Merck Pharmaceutical has also developed its own drugs in cardiovascular disease. 7 Like other pharmaceutical companies, they continue to sell their branded products as long as they can once they have gone off patent but at a lower price in order to meet generic competition. Cost conscious HMO's increase this downward price pressure. Yet, according to Merck some demand for the branded product continues once they adjust the price downward.This is due to better quality, consistent dosage, and brand awareness of the original. Strategically, Merck sees itself as a growth company with a growth target of about 15% per year. This signals a continuing need for cash flow, i. e. from existing drugs, and a Merck sold its share to Dupont in 1998 for over $4billion, apparantly due to its ability to manage more drugs itself. 29 constant flow of new drugs, i. e. from R&D. They need this growth to continue to offer their shareholders the return they expect and to attract the personnel they need to develop drugs which is their corporate mission.Their products now cover 15-16 therapeutic categories. In five years this will expand to between 20 and 25 categories depending on the success of various stages of drug testing. Important new products in the pipeline include Singulair for asthma, Aggrastat for cardiovascular disorders, Maxalt for migraine headaches, and VIOXX, an anti-inflammatory drug, which works as a selective inhibitor targeted at rheumatoid arthritis. They are in phase III trials for all of these new drugs. Propecia for male pattern baldness recently received FDA approval. Merck's R is done internationally.To avoid duplicate investmen t, each research center tends to be focused. For example, the Neuroscience Research Centre in the Untied Kingdom focuses on compounds which affect the nervous system. Maxalt was developed in this Centre. The one laboratory in Italy studies viruses; while the one laboratory in Tsukuba, Japan (Banyu Pharmaceuticals) emphasizes the circulatory system, antibiotics, and anti-cancer research (Giga, Ueda and Kuramoto 1996). This concentration pattern often reflects the comparative strengths in R and the therapeutic demand structure in each local market.Still, selecting the appropriate R projects while critical to their success is very difficult. This is because no discipline in science has as blurred a distinction between basic and applied research as biotechnology. The distinction is usually not well-defined because applied research often contributes to basic research. Indeed, in molecular biology, science often follows technology. Still, as a general approach, Merck tries to focus on app lied research and development rather than basic science. They rely on universities and smaller biotech firms for the later.However, they do some basic research. For instance, th